Biochem/physiol Actions

Reversible: yes

Product competes with ATP.

Target IC₅₀: 280 nM inhibiting Src

Cell permeable: yes

General description

A potent inhibitor of Src-family protein tyrosine kinases. Inhibits Src (IC₅₀ = 280 nM) as well as closely related kinases Fyn (IC₅₀ = 170 nM), Yes (IC₅₀ = 20 nM) and Lyn (IC₅₀ = 130 nM). The inhibition is competitive with respect to ATP. Has only a trivial effect on Lck (IC₅₀ = 6.88 µM). Does not affect the activity of PDGF-β receptor kinase (IC₅₀ >10 µM) and IGF-1 receptor kinase (IC₅₀ gt;20 µM).

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Packaging

Packaged under inert gas

500 µg in Plastic ampoule

Physical form

A 10 mM (500 µg/135 µl) solution of SU6656 (Cat. No. 572635) in DMSO.

Warning

Toxicity: Irritant (B)